Centenary was the first church built in Winchester, about 1749, and served by Missionary Ministers.

In 1842 the German Reformed Church was built in the present location, the corner of Cameron and Cork Streets, commemorating the 100th anniversary of the Reformed Church in the Shenandoah Valley. This church was so badly burned from use by union soldiers that it was necessary to rebuild. The present structure was dedicated August 4, 1906 and continues with celebration, praise and worship to the present.

The Evangelical and Reformed Church was formed in 1934. In 1957 the Congregational Christian Church merged with the Evangelical and Reformed Church to become the United Church of Christ.

Today, Centenary has dedicated and committed members who love God and the Church. Centenary is proud of their heritage and work to preserve it. The church does many missions. Centenary has a Day Care and twice a month Friday Luncheon Program for the homeless and those in need. Centenary sponsors a food bank twice monthly also. Centenary gives support to other UCC Funds and local programs such as the Free Clinic.